General Precautions about Ambien and Using Ambien with Other Drugs


When Ambien is taken along with other benzodiazepine drugs, opioid drugs, antidepressants, or

alcohol, it can lead to a depression of the central nervous system to such a degree that breathing

rates and heart rates drop significantly, resulting in a loss of consciousness, a coma, or even

death. It is not recommended to mix Ambien with other zolpidem products.


Smaller amounts of Ambien are recommended for anyone who is also taking a CPY3A4

inhibitor, such as ketoconazole, which goes by the brand names of Extina, Xolegel, Nizoral,

Xolegel Duo, Ketocon+Plus, Xolegel CorePak, Kuric, Nizoral A-D, and Nizoral Topical.

Sodium oxybate, with the brand name of Xyrem, is known to interact with the effectiveness of

Ambien. Another drug that diminishes how well Ambien works is riframpen, also known as

IsonaRif, Rifamate, Rifater, Rifadin IV, Rimactane and Rifadin.


Ambien should not be mixed with other medications that cause drowsiness or are used to treat

anxiety, such as alprozalam, also called Niravam, Intensol, Alprozolam, Xanax XR and Xanax;

diazepam, with the brand names of Diazepam Intensol, Diastat AcuDial, Diastat, and Valium;

lorazepam, which is also known as Zepnap, Zelor, Urpam-1, Trapex, Olraz, Lorvin, Lorpam-

2, Lorpam-1, Loripam SL, Loripam, Lorel, Lorazepam, Loram, Loralite, Lorakar, Loracalm,

Lopez, Larpose, Lorosh, L. Pam, Calmese, Biokalm, Benj, Ativan, Atipam, Antivan, Anxipose,

Anxionil, Anxilor, Almazine, Lopam, Larosh, Norpose, Lorivan, Biolar, and Almazine; and

muscle relaxants.

Ambien 10 mg - 30 Pills $168.00 Order
Ambien 10 mg - 60 Pills $309.00 Order
Ambien 10 mg - 90 Pills $395.10 Order


Medications with codeine can be another type of drug that shouldn’t be taken with Ambien.

Such drugs go by the brand names of Fioricet with Codeine Guiatuss AC, Floricet with Codeine

Dihistine DH, Phrenilin with Caffeine and Codeine, Iophen-C NR, Cotabflu, Phenylhistine DH, Colrex,

Robitussin-AC, Colrex Compound, Decohistine DH, Tylenol with Codeine #3, Cheratussin AC, Tylenol

with Codeine, Codehist DH, Tylenol with Codeine #4, Endal CD, Cocet, M-End Max D, Phenflu CD,

Airacof, Phenflu CDX, Pro-Clear AC, Maxiflu CD, Triafed & Codeine, Maxiflu CDX, Allerfrin with

Codeine, Rolatuss, Polyhist NC, Fiorinal with Codeine, Triacin C, Fiorinal with Codeine III, Neo AC,

Ascomp with Codeine, Nucodine, Fiortal with Codeine, Cycofed, Soma Compound with Codeine,

Empirin with Codeine, KG-Fed, Nucofed, Nalex AC, Promethazine HCL and Codeine Phosphate,

EndaCof-AC, Codeine PhosphatePromethazine HCI, BroveX CB, Phenergan with Codeine, BroveX CBX,

Promethazine with Codeine, Poly-Tussin AC, Pro-Red AC, M-End PE, Dicomal-PH, BroveX PB C,

ZotexC, BroveX PB XC, Codimal PH, Dietane DC, Penergan VC with Codeine, Myphetane DC,

Promethazine VC with Codeine,Poly-Histine CS, Notuss-PE, Trihist-CS, Ala-Hist AC, MEnd WC,

Tussirex Sugar Free, Mar-cof BP, Tussirex, Notuss-NX, Mytussin CAD, Nasotuss, Guiatuss DAC,

Notuss-NXD, Deproist with Codeine, Statuss Green, Cheratussin DAC, Cotab AX, Endal Expectorant,

Codeprex, Enditussin Expectorant, Notuss-AC, Efasin Expectorant SF,Lexuss 285.00 Liquid, Alphen

Expectorant, CapCof, Maxiphen CDX, T-koff, Maxiphen CD, Pediacof, Giltuss Ped-C, Pedituss, Tridal,

Demi-Cof, and Vanacof CD.


A full night of sleep is required before the effects of Ambien wear off, which usually means

between seven and eight hours of sleep. If fewer hours of sleep take place, it’s recommended to

be careful driving or doing any activity which requires full mental alertness. This is especially

important if Ambien is used with other drugs, as outlined in the previous four paragraphs.

A lack of getting to sleep can be the result of a psychiatric or physical ailment, so it’s important

that a physician make a complete diagnosis of the patient’s condition prior to prescribing

Ambien. Once Ambien is taken for as many as seven to 10 days and getting to sleep is still a

problem, or if there are behavioral alterations or changes in thinking, it might specify a physical

or psychiatric disturbance.


Anaphylactic reactions resulting in a swelling beneath the skin of the tongue or the throat,

labored breathing, the closing of the throat, a nauseous feeling and throwing up can result from

taking Ambien for the first time with some people, which requires a visit to the emergency room

of a hospital, since this type of reaction can be fatal. If such a reaction occurs, Ambien should

not be reused, since it indicates an allergic reaction to the medication. Prior allergic reactions to

Intermezzo, Zolpimist, Edluar or Ambien CR mean you shouldn’t take Ambien.


Cases of unusual behavioral changes can occur with some people who take Ambien, such as

more aggression and an extroverted personality and hearing or seeing something which doesn’t

exist. Some who have taken Ambien have been known to sleep drive, which is driving while

not fully awake. Sleep driving seems to be more pronounce when Ambien is taken along with

alcohol, or other central nervous system depressants.


There are other unusual activities reported by people taking Ambien while they were asleep

and not remembered when they awoke. Such events include preparing meals and eating food,

or placing phone calls and talking on the phone. The difference between regular “sleep talking”

and these conversations is in the typical sleep talking incident, the conversation is incoherent.

But, sleep talk conversations with Ambien make complete sense. Other activities include

sleepwalking, or participating in sex while asleep, which is called sexual parasomnia. If such an

event takes place, it’s recommended to stop taking the medication.


Research performed by the National Prescribing Service in Australia discovered that cases of

unusual events usually happen within days after the starting to take Ambien. Australia’s Sydney

Morning Herald reported in a 2007 article about a man who fell 30 meters (100 feet) off a

balcony to his death while sleep walking while under the influence of Stilnox, another name

for zolpidem, or Ambien. After the story ran, a number of readers responded to the Australian

newspaper with their examples of how the drug created odd incidents of actions taken by them

while sleeping. It prompted Australia’s Adverse Drug Reactions Advisory Committee to review

the medication, as reported by the Sydney Morning Herald. Another death occurred after an

Australian student, by the name of Mairead Costigan, fell 20 meters (65 feet) off the Syndey

Harbour Bridge while using zolpidem.


The following year in Australia, the Therapeutic Goods Administration required that a message

be put on the packaging of zolpidem warning users about its potential to induce peculiar

sleeprelated actions. Furthermore, the warning recommends that zolpidem not be mixed with alcohol

or central nervous system depressant drugs and it warns patients to limit taking the drug to a

maximum of four weeks while under the supervision of a doctor.


If you’re diagnosed with clinical depression, you should not take Ambien, since it can make

depression worse and lead to thoughts of suicide, or intentional overdosing of the medication.

Those with a history of alcohol addiction or abuse should not take Ambien.


Anyone who has problems breathing, or who suffers from sleep apnea or myasthenia gravis

(MG), a neuromuscular disease that makes muscles weak, should use caution when taking

Ambien, since it can reduce the saturation of oxygen in the blood by 80 to 90 percent. If Ambien

is discontinued abruptly, you can receive side effects (see Ambien Side Effects).


Pregnant mothers who used Ambien during the end of their pregnancy can give birth to babies

who suffer breathing problems after birth. Also, babies born to mothers taking drugs such as

Ambien can suffer withdrawal symptoms once they are born. Since Ambien can be found in the

milk of mothers taking the medicine, it should not be used when a woman is nursing.


Seven studies were done to test how Ambien usage might show up in the performance of

individuals the day after using the drug. The tests proved a small, but noteworthy decrease in

performance with elderly patients, as compare to those who were young or middle-age.